This book provides both a rigorous view and a more practical, understandable view of chemical compounds and biochemical engineering and their applications. Every section of the book has been expanded where relevant to take account of significant new discoveries and realizations of the importance of key concepts.
Furthermore, emphases are placed on the underlying fundamentals and on acquisition of a broad and comprehensive grasp of the field as a whole. Bioprocess Engineering Author : Michael L. Shuler Publisher : Pearson College Division Release Date : Genre: Science Pages : ISBN 10 : GET BOOK Bioprocess Engineering Book Description : This concise yet comprehensive text introduces the essential concepts of bioprocessing - internal structure and functions of different types of microorganisms, major metabolic pathways, enzymes, microbial genetics, kinetics and stoichiometry of growth and product information - to traditional chemical engineers and those in related disciplines.
It explores the engineering principles necessary for bioprocess synthesis and design, and illustrates the application of these principles to modern biotechnology for production of pharmaceuticals and biologics, solution of environmental problems, production of commodities, and medical applications. It includes a great deal of new material and has been extensively revised and expanded. All chapters thoroughly revised for current developments, with over pgs of new material, including significant new content in: Metabolic Engineering, Sustainable Bioprocessing, Membrane Filtration, Turbulence and Impeller Design, Downstream Processing, Oxygen Transfer Systems Over new problems and worked examples More than new illustrations.
In biotechnology, the scientist is concerned with developing the most favourable biocatalysts, while the engineer is directed towards process performance, defining conditions and strategies that will maximize the production potential of the biocatalyst. Increasingly, the synergistic effect of the contributions of engineering and life sciences is recognised as key to the translation of new bioproducts from the laboratory bench to commercial bioprocess.
Fundamental to the successful realization of the bioprocess is a need for process engineers and life scientists competent in evaluating biological systems from a cross-disciplinary viewpoint.
Bioprocess engineering aims to generate core competencies through an understanding of the complementary biotechnology disciplines and their interdependence, and an appreciation of the challenges associated with the application of engineering principles in a life science context.
Initial chapters focus on the microbiology, biochemistry and molecular biology that underpin biocatalyst potential for product accumulation.
The following chapters develop kinetic and mass transfer principles that quantify optimum process performance and scale up.
The text is wide in scope, relating to bioprocesses using bacterial, fungal and enzymic biocatalysts, batch, fed-batch and continuous strategies and free and immobilised configurations. Details the application of chemical engineering principles for the development, design, operation and scale up of bioprocesses Details the knowledge in microbiology, biochemistry and molecular biology relevant to bioprocess design, operation and scale up Discusses the significance of these life sciences in defining optimum bioprocess performance.
Score: 4. This book examines the status of bioprocessing and biotechnology in the United States; current bioprocess technology, products, and opportunities; and challenges of the future and what must be done to meet those challenges. It gives recommendations for action to provide suitable incentives to establish a national program in bioprocess-engineering research, development, education, and technology transfer.
It distills the fundamental principles and essential knowledge of cell culture processes from across many different disciplines and presents them in a series of easy-to-follow, comprehensive chapters. Practicality, including technological advances and best practices, is emphasized. This second edition consists of major updates to all relevant topics contained within this work.
The previous edition has been successfully used in training courses on cell culture bioprocessing over the past seven years. The format of the book is well-suited to fast-paced learning, such as is found in the intensive short course, since the key take-home messages are prominently highlighted in panels.
The book is also well-suited to act as a reference guide for experienced industrial practitioners of mammalian cell cultivation for the production of biologics. Liquid Biphasic System: Fundamentals and Applications in Bioseparation Technology explores in detail the fundamental processes and applications of this new separation system, aiding in the understanding of the basic principles of the technique and offering constructive criticisms of the latest findings. Including coverage of the background, principles, mechanisms, and applications, Liquid Biphasic System addresses how to adapt the technology for the purification of useful compounds with greater cost efficiency and greener processing.
It is essential reading for bioprocess engineers, biochemical engineers, biosystem engineers, chemists, and microbiologists working in the fields of bioprocessing.
Researchers, scientists, and engineers concerned with the selection and evaluation of alternative bioseparation processes will find the book particularly useful. Provides information and examples of advanced separations in a single source Includes detailed descriptions of novel bioseparation systems Covers the latest technologies related to advanced liquid—liquid separation and their applications in various industries.
It aims to provide the latest bioprocess technology and explain process analysis from an engineering point of view, using worked examples related to biological systems. This book introduces the commonly used technologies for downstream processing of biobased products. The covered topics include centrifugation, filtration, membrane separation, reverse osmosis, chromatography, biosorption, liquid-liquid separation, and drying.
The basic principles and mechanism of separation are covered in each of the topics, wherein the engineering concept and design are emphasized. This book is aimed at bioprocess engineers and professionals who wish to perform downstream processing for their feedstock, as well as students. They are used in the treatment of uterine atonia, postpartum bleeding, migraine, orthostatic circulatory disturbances, senile cerebral insufficiency, hypertension, hyp- prolactinemia, acromegaly, and Parkinsonism.
Recently, new therapeutic - plications have emerged, e. The broad physiological effects of ergot alkaloids are based mostly on their interactions with neurotransmitter receptors on the cells. The presence of "hidden structures'' resembling some important neu- humoral mediators e. Recycle Reactors 5. Reactive Distillation 5. Reactive Extraction 5. Chapter 6. Kinetic Theory and Reaction Kinetics 6. Unimolecular Reactions 6.
Free Radicals 6. Kinetics of Acid Hydrolysis 6. Parametric Estimation 6. Chapter 7. Enzymes 7. How Enzymes Work 7. Simple Enzyme Kinetics 7. Competitive and Allosteric Enzyme Kinetics 7. Enzyme Inhibition 7. Higher Order Rational Kinetics 7. Temperature Effects 7.
Immobilized Enzyme Systems 7. Analysis of Bioprocess with Enzymatic Reactions 7. Large-Scale Production of Enzymes 7. Medical and Industrial Utilization of Enzymes 7. Chapter 8. Chemical Reactions on Solid Surfaces 8. Chapter 9. Cell Metabolism 9. The Central Dogma 9. Transcription: Sending the Message 9. Translation: Message to Product 9. Metabolic Regulation 9. Overview of Biosynthesis 9. Overview of Anaerobic Metabolism 9. Overview of Autotrophic Metabolism 9.
Chapter Covalent oligomerization Molecular Regulation on Multifunctional Enzymes Rational expressions for catalytic rate How Cells Grow Quantifying Biomass Batch Growth Patterns Effect of Environmental Conditions Heat Generation by Microbial Growth Overview of Cell Growth Kinetic Models Cell Cultivation Batch Culture Continuous Culture Choosing the Cultivation Method Chemostat with Recycle Multistage Chemostat Systems Waste Water Treatment Process Immobilized Cell Systems Solid Substrate Fermentations Fed-batch Operations Evolution and Genetic Engineering Selection Natural Mechanisms for Gene Transfer and Rearrangement Host-Vector System Selection Regulatory Constraints on Genetic Processes Metabolic Engineering Protein Engineering Sustainability: Humanity Perspective CO2 and Biomass Solar Energy
0コメント